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Zolmitriptan

Generic name: zolmitriptan (oral) [ ZOLE-mi-TRIP-tan ]
Brand name: Zomig
Dosage forms: oral tablet (2.5 mg; 5 mg), oral tablet, disintegrating (2.5 mg; 5 mg)
Drug class: Antimigraine agents

Medically reviewed by Drugs.com on Sep 6, 2023. Written by Cerner Multum.

What is zolmitriptan?

Zolmitriptan is a headache medicine that narrows blood vessels around the brain. Zolmitriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.

Zolmitriptan is used to treat migraine headaches in adults.

Zolmitriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

Zolmitriptan should not be used to treat a common tension headache, a headache that causes loss of movement on one side of your body, or any headache that seems to be different from your usual migraine headaches. Use this medication only if your condition has been confirmed by a doctor as migraine headaches.

Zolmitriptan may also be used for purposes not listed in this medication guide.

Zolmitriptan side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Zolmitriptan may cause serious side effects. Stop using zolmitriptan and call your doctor at once if you have:

Common side effects of zolmitriptan may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

You should not use zolmitriptan if you have uncontrolled high blood pressure, heart problems, certain heart rhythm disorders, a history of heart attack or stroke, or circulation problems that cause a lack of blood supply within the body.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Do not use zolmitriptan within 24 hours before or after using another migraine headache medicine.

Before taking this medicine

You should not use zolmitriptan if you are allergic to it, or if you have:

Do not use zolmitriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

To make sure zolmitriptan is safe for you, tell your doctor if you have:

Zolmitriptan disintegrating tablets may contain phenylalanine. Talk to your doctor before using this form of zolmitriptan if you have phenylketonuria (PKU).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether zolmitriptan passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Zolmitriptan is not approved for use by anyone younger than 18 years old.

How should I take zolmitriptan?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use zolmitriptan in larger or smaller amounts or for longer than recommended.

Use zolmitriptan as soon as you notice migraine symptoms.

Take the regular tablet whole with a full glass of water.

To take the orally disintegrating tablet (Zomig-ZMT):

After taking a tablet: If your headache does not completely go away, or goes away and comes back, take a second tablet 2 hours after the first. Do not take more than 10 mg of zolmitriptan in 24 hours. If your symptoms have not improved, contact your doctor before taking any more tablets.

Call your doctor if your headache does not go away at all after taking the first zolmitriptan tablet.

Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse.

Contact your doctor if you have more than four headaches in one month (30 days). Tell your doctor if this medicine seems to stop working as well in treating your migraine attacks.

Zolmitriptan can raise blood pressure to dangerous levels. Your blood pressure may need to be checked often while you are using this medicine. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Since zolmitriptan is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using zolmitriptan.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking zolmitriptan?

Do not take zolmitriptan within 24 hours before or after using another migraine headache medicine, including:

Zolmitriptan may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What other drugs will affect zolmitriptan?

Using zolmitriptan while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called "serotonin syndrome," which can be fatal. Tell your doctor if you also use:

This list is not complete. Other drugs may interact with zolmitriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Popular FAQ

Zomig starts to work quickly, and most people who respond with a single dose will have responded within 1 hour. Some people may take up to 2 hours to experience a decrease in their headache pain. Continue reading

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.