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Zoloft

Generic name: sertralineSER-tra-leen ]
Drug class: Selective serotonin reuptake inhibitors

Medically reviewed by Melisa Puckey, BPharm. Last updated on Aug 23, 2023.

What is Zoloft?

Zoloft is an antidepressant that belongs to a group of drugs called selective serotonin reuptake inhibitors (SSRIs), which works by balancing serotonin levels in the brain and nerves.  Zoloft is used to treat some types of depression, premenstrual dysphoric disorder (PMDD), social anxiety disorder (SAD), obsessive-compulsive disorder (OCD), panic disorder (PD), and post traumatic stress disorder (PTSD).

Warnings

Do not stop taking Zoloft without your doctor's advice.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Before taking this medicine

You should not use Zoloft if you are allergic to sertraline, or if you also take pimozide. Do not use Zoloft oral solution if you take disulfiram (Antabuse).

Do not use Zoloft if you have used an MAO inhibitor in the past 14 days.. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine. Wait at least 14 days after stopping an MAO inhibitor before you take Zoloft ..

Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with sertraline could cause a serious condition called serotonin syndrome.

To make sure Zoloft is safe for you, tell your doctor if you have ever had:

Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Your doctor will need to check your progress on a regular basis. Your family or caregivers should also watch for sudden changes in your behavior.

Zoloft is approved for use in children at least 6 years old, only to treat obsessive-compulsive disorder but not depression.

Taking this medicine during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop Zoloft without asking your doctor.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of sertraline on the baby.

Ask a doctor if it is safe to breastfeed while using Zoloft .

How should I take Zoloft?

Take Zoloft exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Take Zoloft with or without food, at the same time each day.

Zoloft liquid (oral concentrate) must be diluted with a liquid right before you take it. Read and carefully follow all mixing instructions provided with your medicine. Ask your doctor or pharmacist if you need help.

Tell your doctor if you have any changes in sexual function, such as loss of interest in sex, trouble having an orgasm, or (in men) problems with erections or ejaculation. Some sexual problems can be treated.

Measure the mixed medicine with the supplied syringe or the dose-measuring device (not a kitchen spoon).

Sertraline may cause false results on a drug-screening urine test. Tell the laboratory staff that you use Zoloft.

Do not stop using Zoloft suddenly, or you could have unpleasant symptoms (such as agitation, confusion, tingling or electric shock feelings). Ask your doctor before stopping the medicine.

Store tightly closed at room temperature, away from moisture and heat.

Dosing information

Usual Adult Dose for Depression:

Initial dose: 50 mg orally once a day
Maintenance Dose: 50 to 200 mg orally once a day.

Usual Adult Dose for Obsessive Compulsive Disorder:

Initial dose: 50 mg orally once a day
Maintenance Dose: 50 to 200 mg orally once a day.

Usual Adult Dose for Panic Disorder:

Initial dose: 25 mg orally once a day, increased after one week to 50 mg orally once a day
Maintenance dose: 50 to 200 mg orally once a day.

Usual Adult Dose for Post Traumatic Stress Disorder:

Initial dose: 25 mg orally once a day, increased after one week to 50 mg orally once a day
Maintenance dose: 50 to 200 mg orally once a day.

Usual Adult Dose for Social Anxiety Disorder:

Initial dose: 25 mg orally once a day, increased after one week to 50 mg orally once a day
Maintenance dose: 50 to 200 mg orally once a day.

Comments:
-Dose adjustments may be made at intervals of at least one week.
-These conditions generally required several months or longer of sustained pharmacological therapy beyond initial treatment.

Usual Adult Dose for Premenstrual Dysphoric Disorder:

Continuous regimen:
-Initial dose: 50 mg orally once a day during the menstrual cycle
-Maintenance dose: 50 to 150 mg orally once a day during the menstrual cycle

Cyclic regimen:
-Initial dose: 50 mg orally once a day starting 14 days prior to the anticipated start of menstruation through to the first full day of menses, and repeated with each new cycle
-Maintenance dose: 50 to 100 mg orally once a day.

Comments:
-The dose may be increased in increments of 50 mg per menstrual cycle, increased at the onset of each new cycle; dosage adjustments may also include changes between regimens.
-If a 100 mg once daily dose has been established with the cyclic regimen, a titration step of 50 mg per day for three days should be used at the beginning of each dosing period (luteal phase of the menstrual cycle).
-The effectiveness of Zoloft for longer than three months has not been systematically evaluated in controlled trials.

Usual Pediatric Dose for Obsessive Compulsive Disorder:

6 to 12 years:
-Initial dose: 25 mg orally once a day
-Maintenance dose: 25 to 200 mg orally once a day

13 to 17 years:
-Initial dose: 50 mg orally once a day
-Maintenance dose: 50 to 200 mg orally once a day.

Comments:
-The dose may be increased at intervals of at least one week.
-The potential risks versus clinical need should be assessed prior to using this drug in children and adolescents.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Zoloft?

Drinking alcohol with this medicine can cause side effects.

Avoid driving or hazardous activity until you know how Zoloft will affect you. Your reactions could be impaired.

Zoloft side effects

Get emergency medical help if you have signs of an allergic reaction to Zoloft: skin rash or hives (with or without fever or joint pain); difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Zoloft may cause serious side effects. Call your doctor at once if you have:

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Sertraline can affect growth in children. Your child's height and weight may be checked often.

Common side effects of Zoloft may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Zoloft?

Zoloft can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen, naproxen, Advil, Aleve, Motrin, and others. Using an NSAID with Zoloft may cause you to bruise or bleed easily.

Other drugs may interact with sertraline, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Popular FAQ

Sertraline (Zoloft) withdrawal symptoms typically last up to 1 to 2 weeks, but may last even longer in some people. You should avoid abruptly stopping sertraline treatment unless otherwise directed by your healthcare provider. Gradually reducing the dose over 2 to 4 weeks can help to prevent severe withdrawal symptoms in most people. Continue reading

Zoloft (sertraline), a common SSRI antidepressant, can take about 4 to 6 weeks of regular dosing to reach its full therapeutic effect for depression. For other uses, such as obsessive compulsive disorder (OCD) or posttraumatic stress disorder (PTSD), a full effect may take up to 12 weeks of treatment. When prescribed for premenstrual dysphoric disorder (PMDD), benefits may seen in early as the first week during the first menstrual cycle after starting treatment.
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Zoloft (sertraline) may lead to a small weight gain ranging from 1% to 1.6% of initial body weight when used over 6 months to 1 year. In the short-term, weight gain is not significant, but most people need to take Zoloft for an extended period of time. Continue reading

It may take several weeks or longer for an increased dose of Zoloft (sertraline) to take effect. Only use Zoloft at the dosage prescribed by your doctor. Do not increase your dose without first speaking with your doctor. Continue reading

One of the most common side effects with Benadryl is drowsiness, but in some people it can have the opposite effect, known as paradoxical excitation. Instead of feeling sleepy,
you may experience excitation, agitation or insomnia (trouble sleeping), which might make your anxiety symptoms feel worse. This may be more common in young children. Continue reading

No, Zoloft (sertraline) is not a controlled substance. It is in an antidepressant drug class known as selective serotonin reuptake inhibitors (SSRIs). Zoloft is commonly used to treat depression, anxiety, panic attacks and other mood disorders. Doses should be stopped slowly to help prevent withdrawal symptoms. Zoloft can be used for long-term treatment if needed. Continue reading

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Zoloft only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.