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Colesevelam (Oral)

Generic name: colesevelam [ koe-le-SEV-e-lam-hye-droe-KLOR-ide ]
Brand name: Welchol
Drug class: Bile acid sequestrants

Medically reviewed by Drugs.com. Last updated on Jan 5, 2024.

Uses for colesevelam

Colesevelam is used together with proper diet and exercise to lower high cholesterol levels in the blood. This may help prevent medical problems caused by cholesterol clogging the blood vessels. It is also used to lower high blood sugar levels in patients with type 2 diabetes.

Colesevelam works by attaching to food substances in the intestines (bowels). This medicine is not absorbed from the intestines, so these substances pass out of the body without being absorbed.

This medicine is available only with your doctor's prescription.

Before using colesevelam

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of colesevelam to lower high cholesterol levels in the blood in boys and in girls who have had their first menstrual period 10 years of age and older. However, safety and efficacy have not been established to lower high cholesterol levels in the blood in children younger than 10 years of age or in girls before having their first menstrual period and to lower high blood sugar levels in children with type 2 diabetes.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of colesevelam in the elderly. However, elderly patients are more sensitive to the effects of this medicine than younger adults.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Proper use of colesevelam

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Take this medicine with a meal and liquid. Do not swallow the dry powder to prevent esophagus problems.

Swallow the tablet whole. Do not crush, break, or chew it. If you cannot swallow the tablet, use the oral liquid form of this medicine.

To use the oral liquid, mix the contents of the packet in 1 cup (8 ounces) of water, fruit juice, or diet soft drink. Stir well and drink it right away.

If you use this medicine for diabetes, carefully follow the special diet your doctor gave you. This is the most important part of controlling your diabetes and will help the medicine work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

If you use this medicine to lower blood cholesterol, your doctor may change your diet to one that is low in fat, sugar, and cholesterol. Carefully follow your doctor's order about any special diet and exercise regularly.

This medicine can be taken at the same time with a lipid-lowering medicine called a "statin" or the two medicines can be dosed apart. If you need help deciding the best times to take your other medicines, ask your doctor or pharmacist.

If you are taking cyclosporine, glimepiride, glipizide, glyburide, levothyroxine, olmesartan, phenytoin, birth control pills containing ethinyl estradiol and norethindrone, or vitamins, take them at least 4 hours before using colesevelam.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions while using colesevelam

It is very important that the doctor check your or your child's progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

This medicine may increase triglyceride levels in the blood which may cause serious heart problems. Your doctor may check your triglycerides or fatty acids in the blood before using this medicine.

Your doctor may want to measure the cholesterol levels in your blood on a regular basis to make sure this medicine is working properly. Be sure to keep all of your appointments. You will also need to check your blood sugar regularly at home.

Do not stop using this medicine without first checking with your doctor. When you stop using this medicine, your blood cholesterol and sugar levels may increase again.

This medicine can cause low blood sugar (hypoglycemia). The symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). People may feel different symptoms with a low blood sugar. It is important that you learn which symptoms you get when your blood sugar is low. The symptoms of low blood sugar include: anxiety, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool, pale skin, difficulty with thinking, drowsiness, excessive hunger, a fast heartbeat, continuing headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, and unusual tiredness or weakness.

If you have any symptoms of low blood sugar, check your blood sugar level right away. If needed, you can eat glucose tablets or gel, corn syrup, honey, or sugar cubes, or you can drink fruit juice, a non-diet soft drink, or sugar dissolved in water.

Check with your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness. These may be symptoms of acute pancreatitis.

This medicine can cause constipation, and for some people this can be very uncomfortable. If you have problems with severe constipation while using this medicine, talk to your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of colesevelam

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Less common

Incidence not known

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Commonly used brand name(s)

In the U.S.

Available Dosage Forms:

Therapeutic Class: Antihyperlipidemic

Pharmacologic Class: Colesevelam

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.