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Zofran ODT

Generic name: ondansetron (oral) [ on-DAN-se-tron ]
Drug class: 5HT3 receptor antagonists

Medically reviewed by Drugs.com on Aug 3, 2023. Written by Cerner Multum.

The Zofran ODT brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.

What is Zofran ODT?

Zofran ODT blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Zofran ODT is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.

Zofran ODT may be used for purposes not listed in this medication guide.

Zofran ODT side effects

Get emergency medical help if you have signs of an allergic reaction: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat.

Zofran ODT may cause serious side effects. Call your doctor at once if you have:

Common side effects of Zofran ODT may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Zofran ODT side effects (more detail)

Warnings

You should not use Zofran ODT if you are also using apomorphine (Apokyn).

Before taking this medicine

You should not use Zofran ODT if:

To make sure Zofran ODT is safe for you, tell your doctor if you have:

Zofran ODT is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Zofran ODT is not approved for use by anyone younger than 4 years old.

Zofran ODTly disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

How should I take Zofran ODT?

Follow all directions on your prescription label. Do not take Zofran ODT in larger or smaller amounts or for longer than recommended.

Zofran ODT can be taken with or without food.

The first dose of ondansetron is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor's dosing instructions very carefully.

Take the Zofran ODT regular tablet with a full glass of water.

To take the orally disintegrating tablet (Zofran ODT):

To use Zofran ODT soluble film (strip) (Zuplenz):

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Store at room temperature away from moisture, heat, and light. Store liquid medicine in an upright position.

Detailed Zofran ODT dosage information

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.

What should I avoid while taking Zofran ODT?

Zofran ODT may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What other drugs will affect Zofran ODT?

Zofran ODT can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with this medicine.

Taking Zofran ODT while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called "serotonin syndrome," which can be fatal. Tell your doctor if you also use:

This list is not complete and many other drugs can interact with Zofran ODT. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Zofran ODT drug interactions (more detail)

Popular FAQ

Although ondansetron is not specifically approved by the FDA to treat nausea and vomiting during pregnancy (NVP), its use is common, and approximately 25% of pregnant women are prescribed ondansetron to treat NVP. Overall, studies show the use of ondansetron appears to be associated with an additional 3 instances of oral cleft defects (such as cleft lip or cleft palate) for every 10,000 women exposed to ondansetron during their first trimester. There may also be a very slight increased risk of a type of heart defect called a ventricular septal defect, but no apparent increased risk of other birth defects, miscarriage, or fetal death. Continue reading

If you are taking ondansetron for nausea that occurs with meals, then the standard tablet should be taken half an hour to 1 hour before meals, and the orally disintegrating tablet or oral soluble film can be taken 15 minutes before meals. However, if you are taking ondansetron for constant, all day nausea then it should be taken at regular intervals during the day as prescribed, with or without food.

You can take ondansetron more frequently initially, for example, if you are taking it to prevent or treat nausea of vomiting from chemotherapy you can take 4mg then follow up with another 4mg dose at 4 and 8 hours after the first dose. The following day you should only take it every 8 hours (3 times a day). If you continue taking ondansetron more frequently than this you are at higher risk of side effects such as constipation, headache, or heart effects.

Oral ondansetron works quickly, usually within 30 minutes, but it can take up to two hours for the full effect. It’s taken before you receive medicines or procedures that might make you feel nauseous or cause vomiting. Oral doses are usually taken 30 minutes before chemotherapy, 1 hour before surgery, or 1 to 2 hours before radiation treatments. You may need extra doses. Your doctor will tell you exactly when to take your medication.

Yes, ondansetron (Zofran) might make you feel sleepy or tired. Ondansetron injection for the treatment of post-operative nausea and vomiting has been reported to cause drowsiness or sedation in 8% of patients vs. 7% of those using a placebo (an inactive treatment). Malaise (generally feeling unwell) and fatigue (tiredness or lack of energy) have also been reported in 13% of patients (vs. 2% placebo) when it is used orally for the prevention of chemotherapy-induced nausea and vomiting.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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